S. Rogers

Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging

This paper introduces a microfluidics-based thrombus profiling assay that detects intensified biomechanical thrombogenesis in hypertension and aging, revealing a GPIb-integrin mechanosensing axis hyperactivity mechanism.

Suspension Electrospinning of Decellularized Extracellular Matrix

This paper develops a suspension electrospinning method to create pure decellularized extracellular matrix scaffolds that retain bioactivity, demonstrating its versatility across different decellularization techniques and tissue sources.

TOMM40 and TOMM22 of the Translocase Outer Mitochondrial Membrane Complex rescue statin-impaired mitochondrial dynamics, morphology, and mitophagy in skeletal myotubes

This study shows that statin-induced downregulation of TOMM40 and TOMM22 disrupts mitochondrial dynamics, morphology, and mitophagy in skeletal myotubes, and overexpression of these genes rescues these effects.

Tyrosine kinase inhibitor independent gene expression signature in CML offers new targets for LSPC eradication therapy

The paper identifies TKI-independent genes in CML LSC that could be targeted for new therapies, showing that gemtuzumab-ozogamicin and cyclosporine A have stronger effects on CML cells than healthy cells.

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

This study identifies PLK1 as a target of EYA4 and EYA1 phosphatases, showing that dephosphorylation of pY445 promotes PLK1 activation and mitosis, with implications for cancer therapy.

Type-specific EV-D68 real-time RT-PCR assay for the detection of all extant enterovirus D68 strains

The paper develops a real-time RT-PCR assay, CDC2022, that detects all extant EV-D68 strains with 100% sensitivity and specificity.

Triglyceride lipolysis driven by glucose restriction triggers liquid-crystalline phase transitions and proteome remodeling of lipid droplets

The paper shows glucose restriction induces liquid-crystalline phase transitions in lipid droplets by promoting TG lipolysis, which alters lipid composition and remodels the proteome.

Cancer-associated fibroblast-derived ROR2 induces WNT/PCP activation and polarized migration in receiving gastric cancer cells.

The paper shows that cancer-associated fibroblasts transfer ROR2 to gastric cancer cells, activating WNT/PCP signaling and promoting migration.

The scaffolding protein Flot2 regulates cytoneme-based transport of Wnt3 in gastric cancer

This study identifies Flot2 as a regulator of cytoneme-based Wnt3 transport in gastric cancer and shows its conserved role in zebrafish embryogenesis.

Liquid-crystalline lipid phase transitions in lipid droplets selectively remodel the LD proteome

The paper shows glucose restriction induces liquid-crystalline lipid phase transitions in lipid droplets, which selectively remodel the LD proteome and affect ER-LD transport.

Glucose restriction drives spatial re-organization of mevalonate metabolism and liquid-crystalline lipid droplet biogenesis

The paper shows that glucose restriction causes yeast to reorganize mevalonate metabolism at nucleus-vacuole junctions, enhancing lipid droplet formation with liquid-crystalline properties.

The circulatory physiopathology of human red blood cells investigated with a multiplatform model of cellular homeostasis. III. Senescence changes during the full circulatory lifespan

This paper investigates the mechanisms of red blood cell (RBC) senescence during their circulatory lifespan using a multiplatform model, finding that both quantal changes and pump decay are necessary for observed densification and density reversal patterns.

User guide to the red blood cell model (RCM), a multiplatform JAVA-based model of human red blood cell homeostasis

The paper introduces a JAVA-based model of human red blood cell homeostasis and demonstrates its use in studying dehydration and related pathophysiological processes.

The circulatory physiopathology of human red blood cells investigated with a multiplatform model of cellular homeostasis. II. Capillary transits and the role of PIEZO1

This paper uses a multiplatform red blood cell model to study capillary transit effects on RBC homeostasis, finding that PIEZO1 activation causes minimal, biphasic volume changes incompatible with a functional role in capillary flow.

MolNetEnhancer: enhanced molecular networks by integrating metabolome mining and annotation tools

MolNetEnhancer integrates metabolomics tools to improve chemical annotation and structural insight from mass spectrometry data.

Drosophila Snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytes

This study identifies Snazarus as a regulator of lipid droplet organization in Drosophila adipocytes, showing its role in maintaining peripheral lipid droplets at plasma membrane contacts.

A universal fluorescence-based toolkit for real-time quantification of DNA and RNA nuclease activity

This paper introduces a fluorescence-based assay to measure nuclease activity, kinetics, and substrate preferences, applicable to DNA and RNA nucleases involved in repair and immune processes.