Structural insights into plasticity and discovery of remdesivir metabolite GS-441524 binding in SARS-CoV-2 macrodomain
X. Ni, M. Schroeder, V. Olieric, M. E. Sharpe, V. Olmos, E. Proschak, D. Merk, S. Knapp, A. Chaikuad
The paper reports crystal structures of SARS-CoV-2 nsP3 macrodomain bound to nucleotides and remdesivir metabolites, revealing structural plasticity and potential inhibitor targets.
bioRxiv · Mar 4, 2021Biochemistry