Author

E. Proschak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

S. Knapp· 4 shared A. Kumar· 2 shared J. Heering· 2 shared S. Mueller· 2 shared A. Balzulat· 1 shared A. Chaikuad· 1 shared A. Frank· 1 shared A. Menge· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersBiochemistry

S. Knapp

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Discovery of the sEH Inhibitor Epoxykynin as Potent Kynurenine Pathway Modulator

L. Doetsch, C. Davies, E. Hennes, J. Schoenfeld, A. Kumar, C. Da Cruz Lopes Guita, J. H. M. Ehrler, K. Hiesinger, S. Thavam, P. Janning, S. Sievers, S. Knapp, E. Proschak, S. Ziegler, H. Waldmann

The paper identifies epoxykynin as a potent sEH inhibitor that modulates the kynurenine pathway, offering new opportunities to address cancer-induced immune tolerance.

bioRxiv · Nov 9, 2023Cell Biology

Targeting LC3/GABARAP for degrader development and autophagy modulation

M. P. Schwalm, J. Dopfer, A. Kumar, F. A. Greco, N. Bauer, F. Loehr, J. Heering, S. Cano, S. Lechner, T. Hanke, I. Bekic, V. Morasch, D. Fearon, P. G. Marples, C. W. E. Tomlinson, , V. V. Rogov

The paper evaluates the druggability of LC3/GABARAP for autophagy modulators and identifies ligands that bind to the HP2 pocket of the LIR docking site.

bioRxiv · Oct 5, 2023 · PreprintBiochemistry

Discovery of a new activator of Slack potassium channels with robust efficacy in models of histamine-independent and chronic itch

A. Balzulat, W. F. Zhu, C. Flauaus, V. Hernandez-Olmos, J. Heering, S. Sethumadhavan, M. Dubiel, A. Frank, A. Menge, M. Hebchen, K. Metzner, R. Lu, R. Lukowski, P. Ruth, S. Knapp, , A. Schmidtko

This study identifies compound 6 as a potent Slack potassium channel activator effective in treating histamine-independent and chronic itch without motor side effects.

bioRxiv · Oct 5, 2023 · PreprintPharmacology & Toxicology

Structural insights into plasticity and discovery of remdesivir metabolite GS-441524 binding in SARS-CoV-2 macrodomain

X. Ni, M. Schroeder, V. Olieric, M. E. Sharpe, V. Olmos, E. Proschak, D. Merk, S. Knapp, A. Chaikuad

The paper reports crystal structures of SARS-CoV-2 nsP3 macrodomain bound to nucleotides and remdesivir metabolites, revealing structural plasticity and potential inhibitor targets.

bioRxiv · Mar 4, 2021Biochemistry