M. Schroeder

Comprehensive Interrogation of Synthetic Relationships in the Human DNA Damage Response

The paper maps genetic interactions of DDR genes using CRISPRi screening, identifies key interactions with therapeutic potential, and provides insights into genome maintenance mechanisms.

Epitope Engineered Human Haematopoietic Stem Cells are Shielded from CD123-targeted Immunotherapy

This paper shows that epitope-engineered human hematopoietic stem cells are protected from CD123-targeted immunotherapy while maintaining functionality, offering a strategy for tumor-selective therapy.

Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings

This study develops DCAF1-based PROTACs to overcome CRBN resistance in targeted protein degradation, demonstrating effective degradation of BTK in CRBN-resistant cells.

The BOD1L subunit of the SETD1A complex sustains the expression of DNA damage repair genes despite restraining H3K4 trimethylation

The paper shows that BOD1L in the SETD1A complex maintains DNA repair gene expression despite reducing H3K4 trimethylation, and its loss causes DNA damage and cell death in ESCs.

Diatom adhesive trail proteins acquired by horizontal gene transfer from bacteria serve as primers for marine biofilm formation

The paper identifies diatom-specific adhesive proteins acquired via horizontal gene transfer from bacteria, which function as primers for marine biofilm formation.

Structural insights into plasticity and discovery of remdesivir metabolite GS-441524 binding in SARS-CoV-2 macrodomain

The paper reports crystal structures of SARS-CoV-2 nsP3 macrodomain bound to nucleotides and remdesivir metabolites, revealing structural plasticity and potential inhibitor targets.

Rapid Development of Neutralizing and Diagnostic SARS-COV-2 Mouse Monoclonal Antibodies

This study develops and characterizes high-affinity mouse monoclonal antibodies against SARS-CoV-2, showing their neutralizing and diagnostic potential.

DFG-1 residue controls inhibitor binding mode and affinity providing a basis for rational design of kinase inhibitor selectivity

The paper identifies DFG-1 residues as a target for designing selective kinase inhibitors with non-canonical binding modes, showing that bulky DFG-1 residues enable selectivity over smaller ones.

Catalytic domain plasticity of MKK7 reveals structural mechanisms of allosteric activation and new targeting opportunities

This study presents MKK7 crystal structures and identifies new allosteric targets, revealing structural mechanisms of activation and potential drug candidates.

Selective Vulnerability of Senescent Glioblastoma Cells to Bcl-XL Inhibition

This study identifies Bcl-XL inhibition as a selective vulnerability of senescent glioblastoma cells following radiation or TMZ treatment.

p63 sets the threshold for induction of apoptosis using a kinetically encoded ‘doorbell-like’ mechanism

The paper shows that TAp63 uses a slow third phosphorylation step to set a threshold for apoptosis induction in response to DNA damage.