X-ray and solution structures of human beta-2 glycoprotein I reveal a new mechanism of autoantibody recognition
E. Ruben, W. Planer, M. Chinnaraj, Z. Chen, X. Zuo, V. Pengo, V. De Filippis, R. Alluri, K. McCrae, P. Macor, F. Tedesco, N. Pozzi
This paper reveals the structure of human beta-2 glycoprotein I and shows that its elongated, flexible conformation allows autoantibodies to recognize an epitope without phospholipids.
bioRxiv · Feb 25, 2020Biochemistry