Z. Chen

Mapping fibrotic microenvironments: single-cell and spatial profiling of Schistosoma mansoni-induced tissue fibrosis

This study uses single-cell spatial transcriptomics to map fibrotic microenvironments in Schistosoma mansoni-infected mice, revealing organ-specific fibrosis architecture and shared signaling pairs for potential therapeutic targets.

Vegetation clump size and number as indicators for alternative stable states in semi-arid ecosystems

This study links vegetation clump morphology to bistability in semi-arid ecosystems, suggesting clump changes can indicate an impending desertification transition.

Transcription factor binding site divergence across maize inbred lines drives transcriptional and phenotypic variation

The paper identifies TF binding site divergence between maize inbred lines and links it to gene expression and phenotypic variation.

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

A Drug-Elicitable Alternative-Splicing Module (DreAM) for Tunable AAV Expression and Controlled Myocardial Regeneration

Reversible ubiquitination of integrated domain controls paired NLR immune receptor complex homeostasis

The paper identifies a ubiquitination-deubiquitination cycle regulating the stability and function of the paired NLR receptor complex RRS1/RPS4 in Arabidopsis.

CCDC32 stabilizes clathrin-coated pits and drives their invagination

This study identifies CCDC32 as an endocytic accessory protein that stabilizes clathrin-coated pits and drives their invagination, with mutations linked to cardio-facio-neuro-developmental syndrome.

Muscle Moment Arm-Joint Angle Relations in the Hip, Knee, and Ankle: A Visualization of Datasets

The paper collects and visualizes 300 muscle moment arm datasets to explore hip, knee, and ankle moment arm-joint angle relations.

Joint Moment-Angle/Velocity Relations in the Hip, Knee, and Ankle: A Meta-Visualization of Datasets

The paper meta-visualizes 985 joint moment datasets to explore hip, knee, and ankle moment-angle and moment-velocity relations in musculoskeletal mechanics.

antiCD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8 T cell cytotoxicity after traumatic brain injury

This study shows that anti-CD49d antibody treatment reduces age-related inflammatory responses and CD8 T cell cytotoxicity after traumatic brain injury in mice.

Longitudinal analysis of body weight reveals homeostatic and adaptive traits linked to lifespan in diversity outbred mice

The paper analyzes longitudinal body weight data in mice to identify traits linked to lifespan, finding heritable traits associated with energy homeostasis and longevity.

Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging

This paper introduces a microfluidics-based thrombus profiling assay that detects intensified biomechanical thrombogenesis in hypertension and aging, revealing a GPIb-integrin mechanosensing axis hyperactivity mechanism.

Myocardial infarction creates a critical time window for AAV gene therapy

This paper shows that myocardial infarction creates a time window where AAV gene therapy is more effective in mice, improving gene expression and therapeutic outcomes when administered three days post-infarction.

Unique trajectory of gene family evolution from genomic analysis of nearly all known species in an ancient yeast lineage

The paper analyzes gene family evolution across nearly all known Saccharomycotina yeast species, finding distinct evolutionary patterns with gene loss linked to metabolic and genomic changes.

PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance

The paper identifies PRDX6 as an alternative pathway for selenocysteine metabolism that contributes to ferroptosis resistance in cancer cells.

WUSCHEL-dependent chromatin regulation in maize inflorescence development at single-cell resolution

The paper uses single-cell ATAC-seq to show ZmWUS1 overexpression alters chromatin accessibility in maize inflorescence meristem, revealing its role in stem cell maintenance through context-dependent regulation.

Single-cell and spatial atlas of steatotic liver-related hepatocellular carcinoma

This study characterizes the tumor microenvironment of steatotic liver-related hepatocellular carcinoma using single-cell and spatial transcriptomic analyses, identifying immunosuppressive features and Treg-CAF interactions linked to immunotherapy resistance.

Automated muscle path calibration with gradient-specified optimization based on moment arm

This paper introduces a gradient-specified optimization method to calibrate muscle paths based on desired moment arms, achieving fast and accurate replication of muscle paths from a shoulder-arm model.

Genome Assembly of Docynia delavayi Provides New Insights into α-Farnesene Biosynthesis

This study reports the first high-quality genome of Docynia delavayi and identifies key genes and transcription factors involved in α-farnesene biosynthesis, a major aroma compound in its fruit.

Identification of new markers of angiogenic sprouting using transcriptomics: New role for RND3

The paper identifies a 39-gene signature associated with endothelial cell sprout initiation and reveals a new role for RND3 in filopodial extension during angiogenesis.

UNG-RPA interaction governs the choice between high-fidelity and mutagenic uracil repair

The paper identifies the UNG-RPA interaction as determining whether uracil repair is high-fidelity or mutagenic in B cells.

Arylsulfamates inhibit colonic Bacteroidota growth through a sulfatase-independent mechanism

The paper shows arylsulfamates inhibit Bacteroides growth on sulfated glycans via a lipid kinase, not carbohydrate sulfatases, and identifies resistance mechanisms.

Deciphering the Transcription Factor Landscape in Neuroendocrine Prostate Cancer Progression: A Novel Approach to Understand NE Transdifferentiation

This study identifies lineage-specific transcription factor profiles in prostate cancer progression, revealing dynamic shifts during NE transdifferentiation and proposing a three-phase model.

Mechanisms Of Meristem Maintenance By Maize Transcriptional Corepressors

The paper identifies REL2 and RELK1 as key regulators of maize meristem development, showing they control gene expression to maintain meristem size and influence seed yield.

Efficient Gene Editing and Overexpression of Gametophyte Transformation in a Model Fern

This paper develops a CRISPR/Cas9 system for efficient gene editing and overexpression in the fern Ceratopteris richardii, demonstrating functional effects on stomatal and photosynthetic traits.

Artificial Intelligence-Enabled AlphaFold II Pipeline Guides Functional Fluorescence Labeling of Tubulin Across Species

The paper develops an AI-driven method to label tubulin isotypes in vivo across species, enabling precise visualization of microtubule dynamics and pathogenic variants without disrupting cellular processes.

A peptide targeting outer membrane protein A of Acinetobacter baumannii exhibits antibacterial activity by reducing bacterial pathogenicity

This paper identifies a peptide, P92, that targets AbOmpA of A. baumannii, reducing bacterial pathogenicity without inhibiting growth, showing efficacy in multiple infection models.

Single-cell transcriptional landscape of temporal neutrophil response to burn wound in larval zebrafish

This study maps the temporal neutrophil response to burn wounds in larval zebrafish, identifying distinct subsets and their interactions, and links zebrafish myeloid signatures to human burn severity.

p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer

This study shows that degrading p300/CBP in prostate cancer suppresses tumor growth more effectively than inhibiting their activity, highlighting their role in maintaining the active AR enhanceosome.

TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.