X. Zuo

De novo multi-mechanism antimicrobial peptide design via multimodal deep learning

This paper introduces M3-CAD, a deep learning pipeline for designing multi-mechanism antimicrobial peptides to combat multidrug-resistant organisms, showing effectiveness in a skin wound infection model.

The mitochondrial deoxyguanosine kinase is required for female fertility in mice

This study shows that Dguok knockout causes female infertility in mice by impairing ovarian development, oocyte maturation, and mitochondrial function.

Oxytocin alleviated colitis and colitis-associated colorectal tumorigenesis by targeting fucosylated MUC2

This study shows that oxytocin reduces colitis and CAC by enhancing MUC2 fucosylation via OXTR, suggesting it as a potential therapeutic for these conditions.

Inspiration of SARS-CoV-2 envelope protein mutations on pathogenicity of Omicron XBB

The paper analyzes SARS-CoV-2 envelope protein mutations across Omicron sub-variants to assess their impact on pathogenicity, finding that certain mutations correlate with reduced disease severity.

Extracellular matrix stiffness regulates fibroblast differentiation by influencing DNA methyltransferase 1 expression through microtubule polymerization

This study shows that extracellular matrix stiffness influences fibroblast differentiation by modulating DNMT1 expression via microtubule polymerization.

Programming super DNA-enzyme molecules for on-demand enzyme activity modulation

This paper develops a super DNA-enzyme molecule (SDEM) that enables on-demand enzyme activity modulation with improved detection limits and reaction rates compared to free enzymes.

Why SARS-CoV-2 Omicron variant is milder? A single high-frequency mutation of structural envelope protein matters.

The paper identifies a mutation in the SARS-CoV-2 Omicron variant's structural envelope protein that reduces ion channel calcium permeability and acid sensitivity, leading to lower cell damage and cytokine production.

Regional Cell Atlas of Human Intestine Shapes Distinct Immune Surveillance

The paper creates a regional cell atlas of human intestine using single-cell RNA sequencing and spatial transcriptomics, revealing how microenvironment shapes immune surveillance and disease susceptibility.

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

This study reveals how HAP40 orchestrates HTT structure, affecting its interaction with polyglutamine-expanded exon 1, providing insights into Huntington's disease mechanisms.

Ppard Is Essential in Acceleration of Pancreatic Ductal Adenocarcinoma Development by High-Fat Diet in Mutant Kras Mice

This study shows that PPARD promotes pancreatic ductal adenocarcinoma in mutant Kras mice on high-fat diets, and its inhibition could be a therapeutic strategy.

SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damage and constitutes an antiviral target

This study shows the SARS-CoV-2 envelope protein causes ARDS-like damage and identifies channel inhibitors as potential antiviral targets.

X-ray and solution structures of human beta-2 glycoprotein I reveal a new mechanism of autoantibody recognition

This paper reveals the structure of human beta-2 glycoprotein I and shows that its elongated, flexible conformation allows autoantibodies to recognize an epitope without phospholipids.

Suppression of membranous LRP5 recycling, WNT/β-catenin signaling, and colorectal tumorigenesis by 15-LOX-1 peroxidation of PI3P_linoleic acid

This study shows that 15-LOX-1 metabolism of LA in PI3P reduces LRP5 membrane levels, inhibits Wnt/β-catenin signaling, and suppresses colorectal tumorigenesis in mice.