Mitochondrial Respiratory Chain Protein Co-Regulation in the Human Brain
C. Trumpff, E. Owusu-Ansah, H.-U. Klein, A. Lee, V. Petyuk, T. S. Wingo, A. Wingo, M. Thambisetty, L. Ferrucci, N. Seyfried, D. A. Bennett, P. L. De Jager, M. Picard
The paper characterizes co-regulation patterns of mitochondrial respiratory chain proteins in the human brain across three cohorts, finding differential co-regulation between nuclear and mitochondrial DNA-encoded subunits and reduced complex I abundance in Alzheimer's disease.
bioRxiv · Jul 19, 2021Cell Biology