Author

H.-U. Klein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 4

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Organism:human· 4 Assay:proteomics· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

D. A. Bennett· 4 shared A. Wingo· 2 shared C. Trumpff· 2 shared L. Ferrucci· 2 shared M. Picard· 2 shared M. Thambisetty· 2 shared N. Seyfried· 2 shared P. De Jager· 2 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersCell Biology

D. A. Bennett

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4 papers

Recent·Most cited

Psychosocial experiences are associated with human brain mitochondrial biology

C. Trumpff, A. Monzel, C. Sandi, V. Menon, H.-U. Klein, M. Fujita, A. J. Lee, V. A. Petyuk, C. Hurst, D. A. Duong, N. Seyfried, A. Wingo, T. S. Wingo, Y. Wang, M. Thambisetty, , M. Picard

This study links psychosocial experiences to mitochondrial biology in the human brain, finding positive experiences correlate with higher OxPhos machinery abundance and negative experiences with lower abundance.

bioRxiv · Oct 6, 2023Cell Biology

Mitochondrial Respiratory Chain Protein Co-Regulation in the Human Brain

C. Trumpff, E. Owusu-Ansah, H.-U. Klein, A. Lee, V. Petyuk, T. S. Wingo, A. Wingo, M. Thambisetty, L. Ferrucci, N. Seyfried, D. A. Bennett, P. L. De Jager, M. Picard

The paper characterizes co-regulation patterns of mitochondrial respiratory chain proteins in the human brain across three cohorts, finding differential co-regulation between nuclear and mitochondrial DNA-encoded subunits and reduced complex I abundance in Alzheimer's disease.

bioRxiv · Jul 19, 2021Cell Biology

BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 implicated in Tau pathology

M. Taga, V. A. Petyuk, C. White, G. Marsh, Y. Ma, H.-U. Klein, S. M. Connor, A. Khairallah, M. Olah, J. Schneider, R. Ransohoff, D. A. Bennett, A. Crotti, E. M. Bradshaw, P. L. De Jager

The paper identifies BIN1 protein isoforms expressed in astrocytes, neurons, and microglia, finding that neuronal and astrocytic BIN1 containing exon 7 is associated with tau pathology in Alzheimer's disease.

bioRxiv · Jan 31, 2019Cell Biology

A multi-omic atlas of the human frontal cortex for aging and Alzheimer's disease research

P. De Jager, Y. Ma, C. McCabe, J. Xu, B. N. Vardarajan, D. Felsky, H.-U. Klein, C. C. White, M. A. Peters, B. Lodgson, P. Nejad, A. Tang, L. M. Mangravite, L. Yu, C. Gaiteri, , D. A. Bennett

The paper creates a multi-omic atlas of the human frontal cortex using data from aging and Alzheimer's studies, providing insights into brain biology and disease mechanisms.

bioRxiv · Jan 23, 2018Cell Biology