Author

V. Sandoghdar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Approach:microscopy & imaging analysis· 4 Research Focus:cell signaling & trafficking· 3 Assay:imaging· 3 Assay:fluorescence / live-cell microscopy· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

R. Gholami Mahmoodabadi· 4 shared A. D. Kashkanova· 3 shared M. Blessing· 3 shared A. Gemeinhardt· 2 shared A. Schambony· 2 shared H. Mirzaalian Dastjerdi· 2 shared R. W. Taylor· 2 shared A. Giessl· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersBiophysics

R. Gholami Mahmoodabadi

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8 papers

Recent·Most cited

Measuring concentration of nanoparticles in polydisperse mixtures using interferometric nanoparticle tracking analysis (iNTA)

A. D. Kashkanova, D. Albrecht, M. Kueppers, M. Blessing, V. Sandoghdar

This paper introduces iNTA to measure nanoparticle concentrations in polydisperse mixtures without calibration, validated on known samples and SARS-CoV-2 supernatants.

bioRxiv · Jan 9, 2024 · PreprintBiophysics

Interferometric nanoparticle tracking analysis enables label-free discrimination of extracellular vesicles from large lipoproteins

A. D. Kashkanova, M. Blessing, M. Reischke, A. S. Baur, V. Sandoghdar, J. Van Deun

This study applies interferometric nanoparticle tracking analysis to distinguish extracellular vesicles from lipoproteins in plasma and artificial mixtures, showing its superior accuracy over conventional NTA.

bioRxiv · Nov 11, 2022Biophysics

Deciphering a hexameric protein complex with Angstrom optical resolution

H. Mazal, F.-F. Wieser, V. Sandoghdar

This paper introduces polarCOLD, a method combining partial labeling and polarization encoding to achieve Angstrom-resolution 3D structure determination of protein complexes.

bioRxiv · Nov 18, 2021Biophysics

Precision size and refractive index analysis of weakly scattering nanoparticles in polydispersions.

A. D. Kashkanova, M. Blessing, A. Gemeinhardt, D. Soulat, V. Sandoghdar

This paper introduces iNTA, a method combining interferometric scattering and nanoparticle tracking analysis to precisely measure size and refractive index of nanoparticles in suspensions, demonstrating its application to extracellular vesicles and urine nanoparticles.

bioRxiv · Nov 13, 2021Biophysics

Optimized analysis for sensitive detection and analysis of single proteins via interferometric scattering microscopy

H. Mirzaalian Dastjerdi, M. Dahmardeh, A. Gemeinhardt, R. Gholami Mahmoodabadi, H. Köstler, V. Sandoghdar

The paper develops algorithms for analyzing iSCAT data to improve sensitivity and accuracy in detecting single proteins, and provides a Python platform for these methods.

bioRxiv · Aug 16, 2021Biophysics

High-precision protein-tracking with interferometric scattering microscopy

R. W. Taylor, C. Holler, R. Gholami Mahmoodabadi, M. Küppers, H. Mirzaalian Dastjerdi, V. Zaburdaev, A. Schambony, V. Sandoghdar

This paper applies interferometric single particle tracking to study the mobility of epidermal growth factor receptor in live cells with high spatial and temporal resolution.

bioRxiv · Aug 3, 2020Biophysics

Differential diffusional properties in loose and tight docking prior to membrane fusion

A. Witkowska, S. Spindler, R. Gholami Mahmoodabadi, V. Sandoghdar, R. Jahn

The paper uses iSCAT microscopy to study diffusion properties of vesicles during membrane docking, finding decreased diffusion coefficients during intermediate states.

bioRxiv · Mar 28, 2020Biophysics

Interferometric scattering microscopy reveals microsecond nanoscopic protein motion on a live cell membrane

R. W. Taylor, R. Gholami Mahmoodabadi, V. Rauschenberger, A. Giessl, A. Schambony, V. Sandoghdar

This study uses interferometric scattering microscopy to track nanoscale protein motion on live cell membranes with high temporal and spatial resolution.

bioRxiv · Aug 27, 2018Biophysics