D. Albrecht

Measuring concentration of nanoparticles in polydisperse mixtures using interferometric nanoparticle tracking analysis (iNTA)

This paper introduces iNTA to measure nanoparticle concentrations in polydisperse mixtures without calibration, validated on known samples and SARS-CoV-2 supernatants.

The Vaccinia virus chondroitin sulfate binding protein drives host membrane curvature to facilitate fusion

This study shows that the vaccinia virus D8 protein drives host membrane curvature to facilitate fusion by guiding virion binding orientation and promoting membrane invagination.

Poxviruses package viral redox proteins in lateral bodies and modulate the host oxidative response

This study identifies the proteome of poxvirus lateral bodies and shows they contain redox proteins that modulate host oxidative stress responses.

Modulation of early host innate immune response by a Fowlpox virus (FWPV) lateral body protein

This study identifies FPV184 as a Fowlpox virus protein that suppresses host IFN responses by inhibiting promoter activation and localizing to viral lateral bodies.

Cellular polarity asymmetrically functionalizes pathogen recognition receptor-mediated intrinsic immune response in human intestinal epithelium cells

The paper shows that AP-1B-mediated polarized sorting of TLR3 leads to an asymmetric immune response in human intestinal epithelial cells to basolateral vs. apical infections.

A robust metaproteomics pipeline for a holistic taxonomic and functional characterization of microbial communities from marine particles

This paper develops a robust metaproteomics pipeline for analyzing marine particle-associated bacteria, identifying over 5,000 protein groups and revealing functional differences between free-living and particle-associated communities.

Fix your membrane receptor imaging: Actin cytoskeleton and CD4 membrane organization disruption by chemical fixation

The paper shows that fixation methods affecting the actin cytoskeleton alter CD4 membrane organization in super-resolution microscopy.

Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance

This paper shows that type I and III interferons induce interferon stimulated genes with different kinetics, and these differences are intrinsic to the signaling pathways, not receptor abundance.

Nanoscale Polarization of the Vaccinia Virus Entry Fusion Complex Drives Efficient Fusion

This study uses super-resolution microscopy to show that vaccinia virus fusion proteins are polarized at virion tips, and disrupting this polarization reduces fusion efficiency.

NanoJ-SQUIRREL: quantitative mapping and minimisation of super-resolution optical imaging artefacts

NanoJ-SQUIRREL quantitatively maps and minimizes super-resolution imaging artefacts by comparing diffraction-limited and super-resolution images across various techniques.

Revealing compartmentalised membrane diffusion in living cells with interferometric scattering microscopy

This study uses interferometric scattering microscopy to track membrane protein motion in live neurons, revealing compartmentalized plasma membrane structures.