Author

V. Santosh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Assay:cryo-EM· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

C. R. Escalante· 2 shared R. Jaiswal· 2 shared A. Chowdhury· 1 shared A. Washington· 1 shared B. Braud· 1 shared B. Gupta· 1 shared B. Vandewinkel· 1 shared C. Dierckx· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

C. R. Escalante

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3 papers

Recent·Most cited

Cryo-EM Structure of AAV2 Rep68 bound to integration site AAVS1: Insights into the mechanism of DNA melting

R. Jaiswal, V. Santosh, B. Braud, A. Washington, C. R. Escalante

The paper reports Cryo-EM structures of AAV2 Rep68 bound to DNA at the AAVS1 integration site, revealing conformational changes and DNA distortion mechanisms during replication.

bioRxiv · Apr 2, 2024Biochemistry

PITAR, a DNA damage-inducible Cancer/Testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA

S. Jana, M. Mondal, S. Mahale, B. Gupta, K. R. Prasasvi, L. Kandasami, N. Jha, A. Chowdhury, V. Santosh, C. Kanduri, K. Somasundaram

This paper identifies PITAR, a long noncoding RNA that inactivates p53 by stabilizing TRIM28 mRNA, and shows its role in glioblastoma progression and resistance to chemotherapy.

bioRxiv · Apr 11, 2023Cancer Biology

The Cryo-EM structure of AAV2 Rep68 in complex with ssDNA reveals a malleable AAA+ machine that can switch between oligomeric states.

V. Santosh, F. N. Musayev, R. Jaiswal, F. Zarate-Perez, B. Vandewinkel, C. Dierckx, M. Endicott, K. Sharifi, K. Dryden, E. Henckaerts, C. R. Escalante

This study determines the Cryo-EM structure of AAV2 Rep68 bound to ssDNA, revealing its ability to switch between oligomeric states through conformational changes.

bioRxiv · Jun 2, 2020Biochemistry