Intraductal patient derived xenografts of estrogen receptor positive breast cancer recapitulate the histopathological spectrum and metastatic potential of human lesions
C. Brisken, M. Fiche, G. Sflomos, A. Treboux, A. Stravodimou, V. Scabia, A. Ayyanan, Reseau Lausannois du Sein, K. Zaman, L. Battista
The paper establishes that intraductal patient-derived xenografts (ID-PDXs) of ER+ breast cancer replicate histopathological features and metastatic potential, suggesting early tumor dissemination.
bioRxiv · Sep 11, 2018Cancer Biology