The mitochondrial thiolase ACAT1 regulates monocyte/macrophage type I interferon via epigenetic control.
J. Wu, K. SIngh, V. Shing, A. K. Gupta, R. D. Huffstutler, D.-Y. Lee, M. N. Sack
This study shows ACAT1 regulates type I interferon via epigenetic control by linking fatty acid metabolism to histone acetylation in macrophages.
bioRxiv · Jan 29, 2024 · PreprintImmunology