K. Singh

Insulin signaling accelerates the anterograde movement of Rab4 vesicles in axons through Klp98A/KIF16B recruitment via Vps34-PI3Kinase

This study shows insulin signaling increases Rab4 vesicle transport in axons by recruiting Klp98A via Vps34-PI3Kinase activation in Drosophila.

IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models

This study shows that IL-7-expanded autologous lymphocytes increase VLA-4 expression and accumulate in glioblastoma tumors, enhancing the effectiveness of T cell-based therapies.

Bridging fungal resistance and plant growth through constitutive overexpression of Thchit42 gene in Pelargonium graveolens

This study overexpresses the Thchit42 gene in Pelargonium graveolens to enhance fungal resistance and plant growth, showing increased leaf size and oil content.

The mitochondrial thiolase ACAT1 regulates monocyte/macrophage type I interferon via epigenetic control.

This study shows ACAT1 regulates type I interferon via epigenetic control by linking fatty acid metabolism to histone acetylation in macrophages.

Impact of CRISPR/HDR-editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques

This study compares CRISPR/HDR and lentiviral transduction effects on HSPC engraftment and clonal dynamics in rhesus macaques, finding HDR-edited cells decline rapidly while lentiviral cells persist longer.

Tyrosine transfer RNA levels and modifications during blood-feeding and vitellogenesis in the mosquito, Aedes aegypti

The paper examines tRNA abundance and modifications in Aedes aegypti during blood-feeding and vitellogenesis, finding increased tyrosine tRNA transcription is critical for egg yolk protein synthesis.

ACSL4 activity drives TNBC metastasis by positively regulating Histone H3 Acetylation mediated SNAIL expression

This study identifies ACSL4 as a driver of TNBC metastasis by enhancing histone acetylation and SNAIL expression through metabolic and epigenetic mechanisms.

Social Determinants modulate NK cell activity via obesity, LDL, and DUSP1 signaling

The paper links adverse social determinants of health to NK cell dysfunction through obesity, LDL, and DUSP1 signaling in African-American women.

Investigating the effects of radiation, T cell depletion, and bone marrow transplantation on murine gut microbiota

This study examines how radiation, T cell depletion, and bone marrow transplantation affect the gut microbiota in mice, revealing region-specific changes and the impact of T cells on microbial composition.

The D84G mutation in STIM1 causes nuclear envelope dysfunction and myopathy in mice

This study shows that the D84G mutation in STIM1 causes nuclear envelope dysfunction and myopathy in mice by disrupting nuclear-cytosolic Ca2+ coupling.

A standardized quantitative analysis strategy for stable isotope probing metagenomics

This paper introduces a standardized analysis framework and R package for quantifying isotopic enrichment in SIP metagenomics to identify active microbial genomes.

Improved Modeling of Droplet Motion in Open-Format Digital Microfluidic Devices

The paper simulates two electrowetting theories to predict droplet velocity in EWOD devices and compares results with experimental data for ETFE and cling film.

Latent Transforming Growth Factor β Binding Protein 3 Controls Adipogenesis

This study shows that LTBP3 is required for adipogenesis by modulating TGFβ activity in both in vitro and in vivo models.

pH Effect on Ligand Binding to an Enzyme Active Site

This study uses simulations to investigate how pH affects guanidinium ion binding to the active site of hen-egg white lysozyme, revealing key binding pathways and the role of protonation states.

Impact of the aryl hydrocarbon receptor on Aurora A kinase and the G2/M phase pathway in hematopoietic stem and progenitor cells

This study investigates how the aryl hydrocarbon receptor (AHR) regulates gene expression and cell cycle progression in hematopoietic stem and progenitor cells (HSPCs) through transcriptomic and flow cytometric analyses.

Cold stress upregulates the expression of heat shock and Frost genes, but the evolution of cold stress resistance is apparently not mediated through either heat shock or Frost genes in the cold stress selected populations of Drosophila melanogaster

The study examines gene expression and lipid levels in cold-stressed Drosophila populations, finding upregulated heat shock and Frost genes but no significant differences between selected populations.

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

This study delivers IL2 to astrocytes in the brain to increase resident Tregs and protect against neuroinflammation without affecting the peripheral immune system.

A three-dimensional human adipocyte model of fatty acid-induced obesity

This paper develops a 3D in vitro model of human adipocytes to study fatty acid-induced obesity and its associated pathologies.

Pancreatic cancer ductal cell of origin drives CD73-dependent generation of immunosuppressive adenosine

This study identifies CD73 as a key driver of immunosuppression in pancreatic ductal adenocarcinoma, showing its role in adenosine generation and tumor progression.

A single-cell approach reveals variation in cellular phage-producing capacities

This study estimates single-cell bacteriophage lambda burst sizes and shows that burst size variation is due to cellular production capacity rather than lysis timing noise.

The nuclear effector ArPEC25 from the necrotrophic fungus Ascochyta rabiei targets the chickpea transcription factor CaβLIM1a and negatively modulates lignin biosynthesis for host susceptibility

The Ascochyta rabiei effector ArPEC25 enters the host nucleus and targets the transcription factor CaβLIM1a to manipulate phenylpropanoid pathway for negative modulation of chickpea lignin biosynthesis.

Effect of EMS induced mutation in rice cultivar Nagina 22 on salinity tolerance

The paper screens EMS-induced rice mutants for salinity tolerance, finding 10 mutants surviving high salinity with improved growth and Na exclusion.

Variability in an effector gene promoter of a necrotrophic fungal pathogen dictates epistasis and effector-triggered susceptibility in wheat

This study identifies a promoter element in the Tox1 gene of Parastagonospora nodorum that regulates effector expression and susceptibility in wheat, revealing its role in pathogen virulence and host resistance.

Metabolic design in a model of extreme mammalian metabolism, the North American least shrew (Cryptotis parva)

The paper examines mitochondrial structure and function in the least shrew, revealing organ-specific adaptations in mitochondrial networks and protein composition related to metabolic demand.

Somatic mutations in CTCF zinc fingers produce cellular phenotypes explained by structure-function relationships

This study identifies somatic CTCF mutations in cancer and shows how their structure-function relationships affect cellular phenotypes and tumour suppressor function.

Context-dependent effects of IL-2 rewire immunity into distinct cellular circuits

This study identifies context-dependent effects of IL-2 on immune circuits by rewiring its production sources in mice, revealing distinct cellular responses and potential adverse effects.

Granzyme B prevents aberrant IL-17 production and intestinal pathogenicity in CD4+ T cells

This study shows granzyme B reduces IL-17 production and intestinal inflammation in CD4+ T cells by modulating their differentiation.

Modulation of fungal virulence through CRZ1 regulated F-BAR-dependent actin remodeling and endocytosis in chickpea infecting phytopathogen Ascochyta rabiei

This study identifies an F-BAR domain protein, ArF-BAR, in the fungus Ascochyta rabiei that regulates endocytosis and virulence in chickpea plants, with its expression controlled by the transcription factor ArCRZ1.

Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243A>G mtDNA mutation

The paper shows that the m.3243A>G mtDNA mutation activates the PI3K-Akt-mTORC1 pathway, which can be inhibited to reduce mutant mtDNA load and improve cellular function.

Dysregulation in mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells

The paper identifies dysregulation in mTOR/HIF-1 signaling in SARS-CoV-2 infected cells through proteo-transcriptomics analysis.