A quantitative and predictive model for RNA binding by human Pumilio proteins
I. Jarmoskaite, S. K. Denny, P. P. Vaidyanathan, W. R. Becker, J. O. L. Andreasson, C. J. Layton, K. Kappel, V. Shivashankar, R. Sreenivasan, R. Das, W. J. Greenleaf, D. Herschlag
The paper develops a predictive model for RNA binding by human PUM1 and PUM2 using RNA-MaP data, showing residue flipping and positional coupling, and validates it against in vivo crosslinking data.
bioRxiv · Aug 29, 2018Biochemistry