Pharmacodynamic evaluation of AUM001/tinodasertib, an oral inhibitor of mitogen-activated protein kinase (MAPK)-interacting protein kinase 1, 2 (MNK1/2) in preclinical models and tissues from a Phase 1 clinical study
B. H. Gan, L. H. Lee, R. Takeda, M. Yasin, V. Teneggi, K. Ethirajulu, P. Yeo, D. Umrani, V. Pendharkar, D. W. T. Lim, G. Li, Q. Lu, Y. Cao, R. Nellore, S. Blanchard, , V. Novotny-Diermayr
This paper evaluates the pharmacodynamic effects of AUM001/tinodasertib in preclinical models and human tissues from a Phase 1 study, showing dose-dependent inhibition of eIF4E phosphorylation in tumors and PBMCs.
bioRxiv · Feb 23, 2024 · PreprintCancer Biology