A peptide-neurotensin conjugate that crosses the blood-brain barrier induces pharmacological hypothermia associated with anticonvulsant, neuroprotective and anti-inflammatory properties following status epilepticus in mice
Lotfi Ferhat, Rabia Soussi, Maxime Masse, Grigorios Kyriatzis, Stéphane D. Girard, Fanny Gassiot, Nicolas Gaudin, Mathieu Laurencin, Anne Bernard, Angélique Bôle, Géraldine Ferracci, Maria Smirnova, François S. Roman, Vincent Dive, Salvatore Cisternino, , Michel Khrestchatisky
This paper describes a peptide-neurotensin conjugate that crosses the blood-brain barrier and induces pharmacological hypothermia with neuroprotective effects in a mouse model of status epilepticus.
eLife · Mar 28, 2025Peer-reviewedNeuroscience