Pierre Legrand

This study identifies and characterizes P-motifs in BRCA2 and RAD54B that bind to DMC1 filaments through stable and transient interactions, revealing structural insights into their roles in meiotic recombination.

This study uses electron cryo tomography to reveal the stepwise assembly of SPP1 phage particles from membrane-associated precursors within a viral DNA compartment in infected bacteria.

This study presents cryo-EM structures of yeast NHEJ complexes, revealing mechanisms for DNA-end protection and ligation without DNA-PKcs.

The paper quantifies methionine oxidation sensitivity in apo- and Cu-bound PcuC using a methionine-specific probe, showing increased oxidation of coordinating methionines upon Cu binding.

The paper identifies molecular interactions between MAR1 and FUS1 that activate the HAP2 fusogen in Chlamydomonas gametes, revealing how species-specific adhesion initiates gamete fusion.

This study identifies ArfR GTPases in Asgard archaea, showing they are ancestral to eukaryotic Arf family proteins and suggest early evolution of endomembrane systems.

This study reveals how archaeal RPA's winged-helix domain interacts with DNA primase and polymerase, enhancing PriSL activity and providing insights into replication regulation.

This paper explains how BRCA2's FxxA and FxPP motifs bind to DMC1 and RAD51 via distinct interfaces, stabilizing recombinase filaments and explaining functional differences between these proteins.

The paper identifies a conserved binding site on bacterial replicative helicases that is targeted by both DciA and DnaC loaders, showing functional interchangeability between these loaders.

This study determines the 3D structure of the PCSK9-CHRD-P1.40 complex and shows how CAP1 and HLA-C interact with PCSK9 to regulate LDLR degradation.

This paper identifies a cryptic BRCA2 repeated motif that binds to HSF2BP oligomers but does not affect meiotic recombination.