Resolving Heterogeneous Mechanical Domains via Physics-Aware Deep Clustering of Single-Molecule Force Spectroscopy Data
Cailong Hua, Yiyuan Zhang, Vinitendra Singh, Rebecca A Walsh, Joseph Vavra, Joseph M. Muretta, James M. Ervasti, Murti V. Salapaka
This paper introduces a physics-aware deep clustering method to identify heterogeneous folding domains in single-molecule force spectroscopy data, revealing distinct mechanical properties in natural proteins.
bioRxiv · Sep 1, 2026 · PreprintBiophysics