The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA viruses
B. Bonaventure, A. Rebendenne, F. Garcia de Gracia, J. McKellar, S. Gracias, E. Labaronne, M. Tauziet, A. L. Chaves Valadao, E. Bernard, L. Briant, N. Gros, W. Djilli, M. Arnaud-Arnould, V. Courgnaud, H. Parrinello, , C. Goujon
This study identifies DDX42 as an intrinsic antiviral inhibitor that restricts HIV-1 and other positive-strand RNA viruses but not negative-strand RNA viruses.
bioRxiv · Oct 28, 2020Microbiology