Human MX1 orchestrates the cytoplasmic sequestration of neo-synthesized influenza A virus vRNPs
J. McKellar, F. Garcia de Gracia, C. Aube, A. L. Chaves Valadao, M. Tauziet, M. Arnaud-Arnould, A. Rebendenne, A. Neyret, E. Labaronne, E. P. Ricci, B. Delaval, R. Gaudin, N. Naffakh, S. Gallois-Montbrun, O. Moncorge, C. Goujon
This study shows human MX1 restricts influenza A virus by sequestering vRNPs in cytoplasmic clusters via dynein and microtubules, reducing viral production.
bioRxiv · Feb 22, 2024 · PreprintMicrobiology