Reduction of Paraoxonase expression followed by inactivation across independent semiaquatic mammals suggests stepwise path to pseudogenization
A. M. Graham, J. M. Jamison, M. Bustos, C. Cournoyer, A. Michaels, J. S. Presnell, R. Richter, D. E. Crocker, A. Fustukjian, M. E. Hunter, L. D. Rea, C. E. Furlong, W. K. Meyer, N. L. Clark
The paper shows that reduced expression and inactivation of the Pon1 gene in aquatic/semiaquatic mammals precedes pseudogenization, suggesting a stepwise loss of function linked to environmental adaptation.
bioRxiv · Sep 29, 2022Evolutionary Biology