Author

W. L. Dean

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:mechanistic / dynamical model· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

J. B. Chaires· 2 shared J. O. Trent· 2 shared L. W. DeLeeuw· 1 shared R. C. Monsen· 1 shared R. D. Gray· 1 shared R. Monson· 1 shared S. Chakravarthy· 1 shared V. Stribinskis· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

J. B. Chaires

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2 papers

Recent·Most cited

The solution structures of higher-order human telomere G-quadruplex multimers

R. C. Monsen, S. Chakravarthy, W. L. Dean, J. B. Chaires, J. O. Trent

The paper determines the solution structures of higher-order human telomere G-quadruplex multimers using structural biology methods and finds they are semi-flexible with mixed G4 conformers and potential drug targeting sites.

bioRxiv · Nov 13, 2020Biophysics

Human POT1 Unfolds G-Quadruplexes by Conformational Selection

J. B. Chaires, R. D. Gray, W. L. Dean, R. Monson, L. W. DeLeeuw, V. Stribinskis, J. O. Trent

This paper investigates how POT1 unfolds human telomeric G-quadruplexes through a conformational selection mechanism, supported by kinetic, thermodynamic, and computational data.

bioRxiv · Jul 2, 2019Biophysics