A nucleoid-associated protein is involved in the emergence of antibiotic resistance by promoting the frequent exchange of the replicative DNA polymerase in M. smegmatis
This study identifies Lsr2 as a nucleoid-associated protein that promotes rapid exchange of the replicative DNA polymerase DnaE1 in M. smegmatis, enhancing DNA lesion repair but reducing antibiotic resistance.
bioRxiv · Jun 12, 2023 · PreprintMicrobiology