Author

W. M. Patrick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 2 Assay:whole-genome sequencing· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. Winstanley· 2 shared A. Rehman· 1 shared B. Brockway· 1 shared D. F. Ackerley· 1 shared D. W. Reid· 1 shared E. J. Dunkley· 1 shared E. M. Williams· 1 shared G. B. Evans· 1 shared

Activity by Year

2019-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersMicrobiology

C. Winstanley

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Assessing the effectiveness of oxathiapiprolin towards Phytophthora agathidicida, the causal agent of kauri dieback disease

R. F. Lacey, M. J. Fairhurst, K. J. Daley, T. A. Ngata-Aerengamate, H. R. Patterson, W. M. Patrick, M. L. Gerth

This study evaluates oxathiapiprolin's effectiveness against P. agathidicida, showing it inhibits mycelial growth, zoospore germination, and oospore formation, with potential for controlling kauri dieback disease.

bioRxiv · Mar 10, 2021Microbiology

A giant leap in sequence space reveals the intracellular complexities of evolving a new function

K. R. Hall, K. J. Robins, M. H. Rich, M. J. Calcott, J. Copp, E. M. Williams, R. F. Little, R. Schwörer, G. B. Evans, W. M. Patrick, D. F. Ackerley

The paper evolves an enzyme to detoxify chloramphenicol, revealing that endogenous substrates significantly influence evolutionary trajectories through epistatic interactions.

bioRxiv · May 27, 2020 · PreprintBiochemistry

Assessment of Phenotype Microarray plates for rapid and high-throughput analysis of collateral sensitivity networks

E. J. Dunkley, J. D. Chalmers, S. Cho, T. J. Finn, W. M. Patrick

This study evaluates Phenotype Microarray plates for identifying collateral sensitivity in bacteria, finding they are useful for large changes but less reliable for subtle examples.

bioRxiv · Jul 5, 2019Microbiology

Genomic and phenotypic comparison of environmental and patient-derived isolates of Pseudomonas aeruginosa suggest that antimicrobial resistance is rare within the environment

K. A. Ramsay, S. J. Wardell, W. M. Patrick, B. Brockway, D. W. Reid, C. Winstanley, S. C. Bell, I. L. Lamont

The paper compares genomic and phenotypic features of environmental and patient-derived Pseudomonas aeruginosa isolates, finding that environmental isolates are rarely resistant to antibiotics.

bioRxiv · Jul 5, 2019Microbiology

A large-scale comparison shows that genetic changes causing antibiotic resistance in experimentally evolved Pseudomonas aeruginosa predict those in naturally evolved bacteria

S. J. T. Wardell, A. Rehman, L. W. Martin, C. Winstanley, W. M. Patrick, I. Lamont

This paper experimentally evolves Pseudomonas aeruginosa to antibiotic resistance and identifies mutations that correlate with clinical isolates, showing their predictive value for resistance mechanisms.

bioRxiv · Jun 18, 2019Microbiology