C. Winstanley

Win-paired cues modulate the effect of dopamine neuron sensitization on decision making and cocaine self-administration: divergent effects across sex

This study shows that dopamine neuron sensitization interacts with win-paired cues to differentially affect risk-taking and cocaine self-administration in male and female rats.

A phospholipase assay screen identifies synergistic inhibitors of the P. aeruginosa toxin ExoU

This study identifies synergistic inhibitors of P. aeruginosa ExoU through a phospholipase assay screen, showing reduced cytotoxicity in vitro and in corneal assays.

Pseudomonas aeruginosa utilises host-derived polyamines to facilitate antimicrobial tolerance

This study shows that Pseudomonas aeruginosa uses host-derived polyamines, like spermidine, to enhance antimicrobial tolerance during infection, despite reduced susceptibility in vitro.

Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity

This study evaluates the effects of fluoroquinolones and aminoglycosides on P. aeruginosa T3SS expression and cytotoxicity in corneal epithelial cell models, finding tobramycin inhibits T3SS and cytotoxicity while fluoroquinolones upregulate T3SS and enhance cytotoxicity.

Dopamine neurons gate the intersection of cocaine use, decision making, and impulsivity

This study shows that inhibiting VTA dopamine neurons reduces risky decision-making and impulsivity in male rats but increases risky choices in females, while also reducing cocaine-induced decision-making deficits but increasing cocaine consumption.

Evaluation of ExoU inhibitors in a Pseudomonas aeruginosa scratch infection assay

This study evaluates ExoU inhibitors in a Pseudomonas aeruginosa scratch infection model, showing their effectiveness in reducing cytotoxicity when combined with antimicrobials.

A megaplasmid family responsible for dissemination of multidrug resistance in Pseudomonas

This study identifies a megaplasmid family in Pseudomonas aeruginosa that spreads multidrug resistance through duplication, recombination, and diverse accessory traits.

Genomic and phenotypic comparison of environmental and patient-derived isolates of Pseudomonas aeruginosa suggest that antimicrobial resistance is rare within the environment

The paper compares genomic and phenotypic features of environmental and patient-derived Pseudomonas aeruginosa isolates, finding that environmental isolates are rarely resistant to antibiotics.

A large-scale comparison shows that genetic changes causing antibiotic resistance in experimentally evolved Pseudomonas aeruginosa predict those in naturally evolved bacteria

This paper experimentally evolves Pseudomonas aeruginosa to antibiotic resistance and identifies mutations that correlate with clinical isolates, showing their predictive value for resistance mechanisms.

Transposable temperate phages promote the evolution of divergent social strategies in Pseudomonas aeruginosa populations

This study shows transposable phages drive divergence in social strategies of Pseudomonas aeruginosa by promoting extreme siderophore production phenotypes in iron-limited environments.

Campylobacter jejuni transcriptome changes during loss of culturability in water

This study identifies gene expression changes in Campylobacter jejuni M1 during loss of culturability in water, revealing adaptations related to stress response and flagellar assembly.