S. Cho

AI-Assisted Discovery and Optimization of Small Molecule TREM2 Agonists with Functional Microglial Activity

Deep Docking virtual screening of over five million compounds and structure-activity optimization yielded T2M-010, a submicromolar small-molecule TREM2 agonist that induces SYK phosphorylation and microglial phagocytosis.

Benzylic Trifluoromethyl Accelerates 1,6-Elimination Toward Rapid Probe Activation

This paper introduces a fluorescent probe that rapidly detects hydrogen sulfide in live cells through a benzylic trifluoromethyl group-enhanced 1,6-elimination reaction.

rRNA Operon Improves Species-Level Classification of Bacteria and Microbial Community Analysis Compared to 16S rRNA

This study compares the accuracy of species-level classification and microbial community analysis using rRNA operon versus 16S rRNA gene and V3-V4 regions, finding the rRNA operon more accurate.

Spatial Effects of Infiltrating T cells on Neighbouring Cancer Cells and Prognosis in Stage III CRC patients

The paper investigates the spatial relationship between T cells and cancer cells in stage III CRC patients, finding that closer proximity of T cells to cancer cells is associated with better disease-free survival.

PET imaging of fibroblast activation protein alpha (FAP) detects incipient cardiotoxicity due to anthracycline chemotherapy

This study shows that PET imaging with [68Ga]Ga-FAPI-04 detects early cardiotoxicity from anthracycline chemotherapy before echocardiography, by targeting fibroblast activation protein alpha (FAP).

Sulfasalazine promotes myogenic differentiation via increasing of fast myosin heavy chain isoforms

This study shows sulfasalazine promotes myogenic differentiation by increasing fast myosin heavy chain isoforms through a metabolic shift to glycolysis in C2C12 myoblasts and improves muscle function in aged and injured mice.

Variable Gain DNA Nanostructure Charge Amplifiers for Biosensing

This paper demonstrates DNA nanostructures that amplify electrochemical biosensing signals through conformational changes, achieving a 2x104-fold response enhancement independent of analyte-DNA interactions.

Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of Th17 immunity

This study identifies intestinal regulatory T cells producing IL-27 to specifically regulate Th17 immunity in the gut, revealing a novel mechanism for tissue-specific immune control.

H3K36M provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis

This study shows that H3K36M oncohistone disrupts epithelial differentiation, increases cellular plasticity, and drives squamous carcinogenesis by altering histone modifications.

Hydrogen and dark oxygen drive microbial productivity in diverse groundwater ecosystems

The paper examines groundwater ecosystems, finding that older groundwaters have higher microbial cell counts and dissolved oxygen, suggesting aerobic microbial activity in previously thought anoxic environments.

TMAO Destabilizes RNA Secondary Structurevia Direct Hydrogen Bond Interactions

This study investigates how TMAO interacts with RNA hairpins using molecular dynamics simulations, revealing that TMAO destabilizes RNA via hydrogen bond interactions with solvent-exposed bases.

Human Digital Twin: Automated Cell Type Distance Computation and 3D Atlas Construction in Multiplexed Skin Biopsies

The paper develops a 3D workflow to analyze multiplexed skin biopsy data, revealing age-related changes in DNA repair and immune cell ratios.

AIMP1-derived peptide secreted from hair follicle stem cells activates dermal papilla cells to promote hair growth

Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate

The paper shows that high nuclear curvature causes lamin-B dilution and rupture, with lamin-A also contributing under high strain rates, suggesting a viscoplastic response to mechanical stress.

ARF4-mediated Retrograde Trafficking Drives Chemoresistance in Glioblastoma

This study identifies ARF4 as a driver of chemoresistance in glioblastoma through a CRISPR screen and shows it mediates retrograde trafficking of EGFR into the nucleus.

Widespread multi-targeted therapy resistance via drug-induced secretome fucosylation

This study identifies drug-induced secretome fucosylation as a mechanism of resistance to targeted therapies across multiple cancers.

Immersive virtual prism adaptation therapy with depth sensing camera: A feasibility study with functional near infrared spectroscopy in healthy adults

This study tests virtual prism adaptation therapy using a depth-sensing camera and fNIRS in healthy adults to assess behavioral and cortical changes during adaptation phases.

An atlas of inter- and intra-tumor heterogeneityof apoptosis competency in colorectal cancertissue at single cell resolution

The paper generates an atlas of apoptosis susceptibility heterogeneity in colorectal cancer using single-cell analysis and ODE modeling, identifying intrinsic cellular differences in apoptosis competency.

Novel Paju Apodemus Paramyxovirus 1 and 2, Harbored by Apodemus agrarius in The Republic of Korea

This study identifies two novel paramyxoviruses, PAPV-1 and PAPV-2, from Apodemus agrarius rodents in Korea, revealing distinct genome structures and zoonotic potential.

Scaling concepts in 'omics: nuclear lamin-B scales with tumor growth and predicts poor prognosis, whereas fibrosis can be pro-survival

The paper identifies scaling relationships between genes in cancer data, finding LMNB1 correlates with poor prognosis while fibrosis markers predict better survival.

Stratification Of Chemotherapy-Treated Stage III Colorectal Cancer Patients Using Multiplexed Imaging And Single Cell Analysis Of T Cell Populations

This study uses multiplexed imaging and single-cell analysis to classify immune cells in stage III colorectal cancer patients, finding that multi-marker Treg classification better predicts survival than single markers.

CTCF-mediated Genomic Effects of BART Region on Epstein-Barr Virus Chromatin 3D Structure in Gastric Carcinoma Cells

This study investigates how CTCF binding at the BARTp site regulates EBV 3D genome structure and gene expression in EBVaGC cells, showing its role in DNA looping and viral infectivity.

Human spinal cord organoids exhibiting neural tube morphogenesis for a quantifiable drug screening system of neural tube defects

This study develops human spinal cord-like organoids (hSCOs) to enable quantitative drug screening for neural tube defects.

Broad-spectrum antiviral activity of 3D8, a nucleic acid-hydrolyzing single chain variable fragment (scFv), targeting SARS-CoV-2 and multiple coronaviruses in vitro

This study demonstrates that 3D8 scFv inhibits replication of SARS-CoV-2, HCoV-OC43, and PEDV in vitro through nucleic acid hydrolysis.

Phenylpropionc acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity

This study shows that phenylpropionic acid from gut microbiota reduces acetaminophen-induced liver damage in mice by inhibiting the toxic enzyme CYP2E1.

Assessment of Phenotype Microarray plates for rapid and high-throughput analysis of collateral sensitivity networks

This study evaluates Phenotype Microarray plates for identifying collateral sensitivity in bacteria, finding they are useful for large changes but less reliable for subtle examples.

Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell cycle arrest

The paper shows that lamin-A stabilizes the genome by protecting against nuclear rupture, DNA damage, and cell cycle arrest under mechanical stress.