Computational modeling of macrophage iron sequestration during host defense against Aspergillus
B. Adhikari, Y. Scindia, L. Sordo Vieira, H. de Assis Lopes Ribeiro, J. Masison, N. Yang, L. Fonseca, M. Wheeler, A. Knapp, Y. Mei, B. Helba, C. Atkinson, W. Schroeder, B. Mehrad, R. Laubenbacher
The paper develops a computational model of macrophage iron sequestration during Aspergillus infection, showing that transferrin receptor-1 upregulation precedes inflammatory cytokine induction.
bioRxiv · Jan 24, 2022Immunology