C. Atkinson

Predicting Primary Graft Dysfunction in Lung Transplantation: Machine Learning-Guided Biomarker Discovery

This study uses machine learning to identify cytokines predictive of primary graft dysfunction in lung transplantation, finding BAL fluid at 2h post-transplant as the strongest predictor.

Lipoxin A4/FPR2 signaling mitigates ferroptosis of alveolar epithelial cells via NRF2-dependent pathway during lung ischemia-reperfusion injury

This study shows that LxA4/FPR2 signaling reduces ferroptosis in alveolar epithelial cells via NRF2 activation, protecting against lung ischemia-reperfusion injury.

MerTK-dependent efferocytosis by monocytic-MDSCs mediates resolution of post-lung transplant injury

This study shows that MerTK-dependent efferocytosis by monocytic-MDSCs reduces post-lung transplant ischemia-reperfusion injury.

Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis

This study shows ferroptosis occurs in kidney tubules of lupus nephritis patients and mice, and a drug can reduce it, suggesting new treatment options.

Computational modeling of macrophage iron sequestration during host defense against Aspergillus

The paper develops a computational model of macrophage iron sequestration during Aspergillus infection, showing that transferrin receptor-1 upregulation precedes inflammatory cytokine induction.

Phenogenomic characterization of a newly domesticated and novel species from the genus Verrucosispora

This study domesticates a novel marine Actinomycetes species, revealing genomic changes linked to growth, metabolism, and antibiotic potential during cultivation.