N. Yang

Loss of H3K9 trimethylation leads to premature aging

This study shows that loss of H3K9me3 in adult mice leads to premature aging, characterized by reduced lifespan, frailty, and accelerated epigenetic aging.

Megabarcoding reveals a tale of two very different dark taxa along the same elevational gradient

The paper uses megabarcoding to show that two Diptera taxa have distinct spatio-temporal distributions along an elevational gradient in a temperate forest.

Liquid-like condensates mediate competition between actin branching and bundling

This study shows that liquid-like condensates containing both actin branching and bundling proteins can modulate the competition between these processes, leading to organized actin structures similar to those in migrating cells.

A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

This study identifies AIRE as a checkpoint in germinal center B cells that limits antibody diversification by inhibiting AID function, leading to autoimmunity and impaired immune responses.

Pneumonic plague protection induced by a monophosphoryl lipid A decorated Yersinia outer-membrane-vesicle vaccine

This study develops a pneumonic plague vaccine using OMV46-LcrV, which shows reduced reactogenicity and complete protection in mice against Y. pestis challenge.

A positive feedback loop between ZEB2 and ACSL4 regulates lipid metabolism to promote breast cancer metastasis

Distributable, Metabolic PET Reporting of Tuberculosis

This paper introduces [18F]FDT, a PET tracer that specifically images Mycobacterium tuberculosis lesions and monitors treatment, enabling global access through a simple synthesis method from [18F]FDG.

Two teosintes made modern maize

This study clarifies the origin of modern maize by showing it resulted from an ancient admixture between domesticated maize and Zea mays ssp. mexicana around 5300 years ago, contributing to genetic and phenotypic diversity.

Taxonomic and carbon metabolic diversification of Bathyarchaeia during its co-evolution history with the early Earth surface environment

This study investigates the evolutionary history and metabolic diversity of Bathyarchaeia, linking their diversification to geological events and environmental changes.

Improved breeding for Fusarium pseudograminarium (Fusarium crown rot) using qPCR measurement of infection in multi-species winter cereal experiments

This paper introduces an improved qPCR method to quantify Fusarium crown rot infection in winter cereals, enabling better breeding for resistance and tolerance.

Innate-adaptive IFN cross-talk reprograms myeloid and T cells for antitumor immunity with a second-generation recombinant MVA

This paper describes a second-generation recombinant MVA vaccine that enhances antitumor immunity by reprogramming myeloid and T cells through innate-adaptive IFN cross-talk.

Molecular Mechanisms of Steric Pressure Generation and Membrane Remodeling by Intrinsically Disordered Proteins

This study measures steric pressure generated by intrinsically disordered domains of AP180 at membrane surfaces, finding that they produce significant pressure through entropic and electrostatic mechanisms, independent of molecular weight.

Tumor-intrinsic PRC2 inactivation drives a context-dependent immune-desert tumor microenvironment and confers resistance to immunotherapy

This study shows that PRC2 inactivation in tumors creates an immune-desert microenvironment, leading to resistance to immunotherapy and suggests strategies to reverse this effect.

Validation of tWO novel primers for THE promising amplification of the mitogenomic Cytochrome c Oxidase subunit I (COI) barcoding region in Artemia aff. sinica (Branchiopoda, Anostraca)

The paper validates two new primers for efficiently amplifying the mtCOI barcoding region in Artemia aff. sinica and related species.

Arbidol inhibits esophageal squamous cell carcinoma growth in vitro and in vivo through suppressing ataxia telangiectasia and Rad3-related protein kinase

This study shows Arbidol inhibits esophageal squamous cell carcinoma growth by targeting the ATR kinase and disrupting the DNA replication pathway.

Computational modeling of macrophage iron sequestration during host defense against Aspergillus

The paper develops a computational model of macrophage iron sequestration during Aspergillus infection, showing that transferrin receptor-1 upregulation precedes inflammatory cytokine induction.

Intratumoral delivery of engineered recombinant modified vaccinia virus Ankara express-ing Flt3L and OX40L generates potent antitumor immunity through activating the cGAS/STING pathway and depleting tumor-infiltrating regulatory T cells

Vaccinia E5 is a major inhibitor of the DNA sensor cGAS

This study identifies Vaccinia E5 as a major inhibitor of the cGAS-STING pathway by promoting cGAS degradation through proteasome-dependent ubiquitination.

MyD88 Mediates Colitis- and RANKL-induced Microfold Cell Differentiation

This study shows MyD88 is essential for M cell differentiation in colitis and RANKL-induced conditions in mice.

Isolation, identification and molecular characterization of Aeromonas spp. from farmed loach (Misgurnus anguillicaudatus)

This study identifies and characterizes Aeromonas species in farmed loaches from China, finding high prevalence of A. veronii and resistance to multiple antibiotics.

Heat-inactivated modified vaccinia virus Ankara boosts Th1-biased cellular and humoral immune responses as a vaccine adjuvant by activating the STING-mediated cytosolic DNA-sensing pathway

This study shows heat-inactivated MVA enhances Th1 immune responses by activating the STING pathway and improves antitumor efficacy when combined with antigens.

Cellular-level phenotyping of tumor-immune microenvironment (TiME) in patients in vivo reveals distinct inflammation and endothelial anergy signatures

The paper uses in vivo cellular-level imaging to phenotype tumor-immune microenvironments, identifying distinct inflammation and endothelial anergy signatures linked to immunotherapy response.

Portrait of a genus: the genetic diversity of Zea

This study maps genetic diversity across Zea species, identifying millions of variants and adaptive genes, and demonstrates their utility in breeding.

EgGLUT1 is crucial for the viability of larvae of Echinococcus granulosus sensus lato by involving its glucose uptake

This study identifies EgGLUT1 as a critical gene for glucose uptake in Echinococcus granulosus s.l. larvae, showing that inhibiting it reduces parasite viability and cyst formation in mice.

Brucella outer membrane proteins to control maturation and antigen presentation of mouse dendritic cells

This study examines how Brucella outer membrane proteins and mutants affect dendritic cell maturation and antigen presentation in mice, revealing their roles in immune evasion and pathogenesis.

DARPP-32 promotes ERBB3-mediated resistance to molecular targeted therapy in EGFR-mutated lung adenocarcinoma

This study identifies DARPP-32 as a mediator of ERBB3-driven resistance to EGFR TKIs in lung adenocarcinoma, showing its role in promoting oncogenic signaling and tumor progression.

Elucidating Mechanisms of Antitumor Immunity Mediated by Live Oncolytic Vaccinia and Heat-Inactivated Vaccinia

This study compares the antitumor effects of live and heat-inactivated oncolytic vaccinia viruses and identifies immune mechanisms underlying their efficacy.

Landscapes and dynamic diversifications of B-cell receptor repertoires in COVID-19 patients

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

A meta-analysis and experiment assessing phage-based FMDV vaccine

This study evaluates phage-based FMDV vaccines through meta-analysis and experiment, showing protective effects and immune responses in mice.

A novel copper-sensing two-component system for activating Dsb genes in bacteria

The paper identifies a novel copper-sensing two-component system, DsbRS, in Pseudomonas aeruginosa that activates the dsbDEG operon involved in copper resistance.