ICOS costimulation is indispensable for the differentiation of T follicular regulatory cells
V. Panneton, B. C. Mindt, Y. Bouklouch, A. Bouchard, S. Mohammaei, J. Chang, M. Witalis, J. Li, A. Stancescu, J. E. Bradley, T. D. Randall, J. H. Fritz, W.-K. Suh
This study shows ICOS costimulation is essential for Tfr cell differentiation during GC reactions and highlights their role in immune tolerance.
bioRxiv · Sep 14, 2021Immunology