Author

Wafaa Achache

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:bacteria (other)· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

Céline CrausteiD· 3 shared Janïs Laudouze· 3 shared Pierre SantucciiD· 3 shared Stéphane CanaaniD· 3 shared Vanessa Point· 3 shared Eliana Sepulveda Ramos· 2 shared Mickaël MazieroiD· 2 shared Gabriela GagoiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

Céline CrausteORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Development of inducible genetic systems to finely tune efficacy of InhA-targeting anti-tuberculous drugs

Eliana Sepulveda Ramos, Maria Sofia Deschutter, Vanessa Point, Thibault Brunet, Janïs Laudouze, Wafaa Achache, Céline Crauste, Stéphane Canaan, Gabriela Gago, Mickaël Maziero, Pierre Santucci

This paper develops CRISPRi-based inducible systems to fine-tune antibiotic susceptibility in Mycobacterium tuberculosis by targeting key genes involved in drug activation.

bioRxiv · Oct 7, 2026 · PreprintMicrobiology

Mycobacterial cell division arrest and smooth-to-rough envelope transition using CRISPRi-mediated genetic repression systems

Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci

This paper describes a CRISPRi-based protocol to assess gene silencing and envelope transitions in Mycobacterium smegmatis as a model for NTM pathogenesis.

FEBS Open Bio · Nov 30, 2025Peer-reviewedMicrobiology

Fluorescence-based CRISPR interference system for controlled genetic repression and live single-cell imaging in mycobacteria

Janïs Laudouze, Vanessa Point, Wafaa Achache, Céline Crauste, Stéphane Canaan, Pierre Santucci

The paper develops and validates fluorescence-based CRISPRi tools for gene repression and live single-cell imaging in mycobacteria.

FEBS Letters · Dec 1, 2024Peer-reviewedMicrobiology