Author
Centre National de la Recherche Scientifique
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
Eliana Sepulveda Ramos, Maria Sofia Deschutter, Vanessa Point…·Pierre Santucci
This paper develops CRISPRi-based inducible systems to fine-tune antibiotic susceptibility in Mycobacterium tuberculosis by targeting key genes involved in drug activation.
Vanessa Point, Wafaa Achache, Janïs Laudouze…·Pierre Santucci
This paper describes a CRISPRi-based protocol to assess gene silencing and envelope transitions in Mycobacterium smegmatis as a model for NTM pathogenesis.
Janïs Laudouze, Tatyana I. Rokitskaya, Akira Abolet…·Pierre Santucci
This study investigates the mechanism of action of pyrazinamide (PZA) in Mycobacterium tuberculosis, showing it kills bacteria by acidifying cytosol via pH-driven weak-acid permeation, independent of PanD and pantothenate levels.
Janïs Laudouze, Thomas Francis, Emma Forest…·Jean‐François Cavalier
The paper evaluates the antimycobacterial activity of salicylic acid derivatives and shows they disrupt intrabacterial pH homeostasis in M. tuberculosis.
Janïs Laudouze, Vanessa Point, Wafaa Achache…·Pierre Santucci
The paper develops and validates fluorescence-based CRISPRi tools for gene repression and live single-cell imaging in mycobacteria.