Author

Thibault Brunet

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Anne-Karin Kahlert· 1 shared Bernard ThienpontiD· 1 shared Camille HumbertiD· 1 shared Céline CrausteiD· 1 shared Damien Conrozier· 1 shared Dorota SzumskaiD· 1 shared Duncan Burnaby SparrowiD· 1 shared Eliana Sepulveda Ramos· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperDevelopmental Biology

Anne-Karin Kahlert

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2 papers

Recent·Most cited

Single-Cell Multimodal Profiling Reveals Maternal Diabetes-Nkx2-5 Interaction in Congenital Heart Disease in a Genetic Model Recapitulating Human Embryopathies

Stéphanie Ibrahim, Julien Maurizio, Nikita Ved, Thibault Brunet, Camille Humbert, Damien Conrozier, Sofian Ameur, Gwenaelle Collod, Dorota Szumska, Jack J. J. J. Miller, Frances Mary Ashcroft, Bernard Thienpont, Anne-Karin Kahlert, Duncan Burnaby Sparrow, Sonia Stefanovic

The paper shows that maternal diabetes and Nkx2-5 haploinsufficiency together cause severe cardiac defects in mice, with single-cell multiomic data revealing transcriptional and chromatin changes.

bioRxiv · Oct 13, 2026 · PreprintDevelopmental Biology

Development of inducible genetic systems to finely tune efficacy of InhA-targeting anti-tuberculous drugs

Eliana Sepulveda Ramos, Maria Sofia Deschutter, Vanessa Point, Thibault Brunet, Janïs Laudouze, Wafaa Achache, Céline Crauste, Stéphane Canaan, Gabriela Gago, Mickaël Maziero, Pierre Santucci

This paper develops CRISPRi-based inducible systems to fine-tune antibiotic susceptibility in Mycobacterium tuberculosis by targeting key genes involved in drug activation.

bioRxiv · Oct 7, 2026 · PreprintMicrobiology