Author

Wei Hu

First Affiliated Hospital Zhejiang University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Immunology· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

Changjie LouiD· 2 shared Hui CheniD· 2 shared Jizhong LouiD· 2 shared Songfang WuiD· 2 shared Wei CheniD· 2 shared Yong Zhang· 2 shared Feng ZhuiD· 1 shared Haibin DaiiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

Changjie LouORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Intrinsic immune receptor triggering mechanism informs rational chimeric receptor design

Songfang Wu, Hui Chen, Qi Wang, Haiyan Qiang, Xin Guan, Yong Zhang, Wei Hu, Wei Chen, Changjie Lou, Jizhong Lou

The paper identifies CD3ε as a primary trigger subunit in TCR activation through phase separation with Lck, leading to the design of TRIG molecules that activate T and NK cells via endogenous receptor signaling.

bioRxiv · Oct 30, 2026 · PreprintImmunology

CD28 Co-stimulation Is Organized by Signaling Condensates and Counteracted by PD-1

Hui Chen, Songfang Wu, Yong Zhang, Wei Hu, Changjie Lou, Wei Chen, Jizhong Lou

This study shows CD28 co-stimulation forms signaling condensates with Lck, which PD-1 modulates by binding and disrupting these structures, leading to engineered CAR T cells with improved antitumor activity.

bioRxiv · Feb 6, 2026 · PreprintImmunology

IE-MOIF: a novel multi-omics early integration framework for biomedical classification and biomarker discovery

Wei Zhang, Minjie Mou, Wei Hu, Mingkun Lu, Hongning Zhang, Yongchao Luo, Hongquan Xu, Hanyu Zhang, Lin Tao, Haibin Dai, Jianqing Gao, Feng Zhu

IE-MOIF improves multi-omics data integration by enhancing information and using attention mechanisms, leading to better biomarker discovery and classification.

medRxiv · Jun 7, 2023 · PreprintGenetic & Genomic Medicine