Qi Wang

Intrinsic immune receptor triggering mechanism informs rational chimeric receptor design

The paper identifies CD3ε as a primary trigger subunit in TCR activation through phase separation with Lck, leading to the design of TRIG molecules that activate T and NK cells via endogenous receptor signaling.

Impaired astrocytic Cx43 syncytial network in lateral habenula affects synaptic connectivity and drives adolescent stress-induced depression

This study identifies impaired astrocytic Cx43 syncytial networks in the lateral habenula as a driver of adolescent stress-induced depression through disrupted synaptic connectivity and neuronal function.

Disease stage-sensitive MFSD2A-caveolae axis insigates hippocampal blood-brain barrier disruption in Alzheimer's disease

The paper identifies MFSD2A loss in hippocampal endothelial cells as an early stage-specific factor contributing to BBB disruption in Alzheimer's disease and shows that restoring MFSD2A can mitigate pathology and cognitive deficits.

A patient-centric therapeutic paradigm uncouples prostate cancer suppression from systemic metabolic collapse

This paper identifies metabolic dysregulation caused by abiraterone in prostate cancer patients and develops Lifehug-9892 to suppress tumors while preserving systemic metabolic health.

Nuclear Cx43 restrains microglial neurotoxicity during brain development

This study identifies a nuclear function of Cx43 in microglia that restricts neurotoxicity during brain development, revealing a channel-independent mechanism involving transcriptional regulation.

A brain-tumour axis links chronic stress to gastric cancer progression through NPY signalling

The paper identifies a brain-tumour axis linking chronic stress to gastric cancer progression via NPY signalling, showing NPY1R as a therapeutic target.

Neuropeptide Y co-opts neuronal ensembles for memory lability and stability

The paper identifies NPY+ interneurons in the ventral hippocampus that regulate memory extinction through distinct sub-ensembles via fast and slow inhibition.

Two TAL effectors of Xanthomonas citri pv. malvacearum target GhSWEET15 as the susceptibility genes for bacterial blight of cotton

This study identifies Tal1b and Tal1 as TAL effectors targeting GhSWEET15 genes, contributing to bacterial blight susceptibility in cotton.

DNA damage response signatures are associated with frontline chemotherapy response and routes of tumor evolution in extensive stage small cell lung cancer

This study identifies three distinct DDR phenotypes in SCLC associated with chemotherapy response and tumor evolution.

Inference of disease-associated microbial gene modules based on metagenomic and metatranscriptomic data

This paper introduces IDAM, a method for inferring disease-associated microbial gene modules from metagenomic and metatranscriptomic data, showing superior performance and reproducibility in inflammatory bowel disease datasets.

Deep spatial proteomic exploration of severe COVID-19-related pulmonary injury in post-mortem specimens

This study creates a spatial proteomic atlas of lung tissues from COVID-19 victims, identifying protein dysregulations and markers of pathological changes.

Hidden genomic diversity of SARS-CoV-2: implications for qRT-PCR diagnostics and transmission

This study analyzes over 7,000 SARS-CoV-2 datasets to reveal genomic diversity, showing iSNVs and small indels drive variation, and highlights implications for qRT-PCR and transmission tracking.

Artemisinin mimics nitric oxide to reduce adipose weight by targeting mitochondrial complexes

This study shows artemisinin reduces visceral adipose weight in obese mice by targeting mitochondrial complexes, mimicking nitric oxide's effects to improve mitochondrial function and reduce inflammation.

Chondroitin Sulfate Flourishes Gut Sulfatase-Secreting Bacteria To Damage Mucus Layers, Leak Bacterial Debris, And Trigger Inflammatory Lesions In Mice

This study shows that chondroitin sulfate feeding in mice increases sulfatase-secreting bacteria, damages mucus layers, and causes systemic inflammation and multi-organ pathologies.

Chondroitin sulfate elicits systemic pathogenesis in mice by interfering with gut microbiota homeostasis

This study shows that chondroitin sulfate induces steatogenesis, atherogenesis, and dementia-like pathogenesis in mice by disrupting gut microbiota homeostasis.