ImmunologybioRxivPreprint
Intrinsic immune receptor triggering mechanism informs rational chimeric receptor design
Songfang Wu, Hui Chen, Qi Wang…·Jizhong Lou
The paper identifies CD3ε as a primary trigger subunit in TCR activation through phase separation with Lck, leading to the design of TRIG molecules that activate T and NK cells via endogenous receptor signaling.
DOI 10.64898/2026.10.24.761481