Wei Sun

A telomere-to-telomere genome of Holstein cattle resolves chromosome-end architecture and the genetic basis of telomere length

This paper presents a telomere-to-telomere genome of Holstein cattle, identifies genetic loci associated with telomere length, and highlights key biological processes involved.

A robust and scalable image analysis framework for phenotyping human thoracic aorta

This paper introduces a framework for automated thoracic aorta phenotyping from CT scans, generating anatomical landmarks, meshes, and biomechanical phenotypes.

Spatial multi-omics and single-cell transcriptomics uncover senescence-associated cellular programs during colon adenoma to cancer progression

The paper uses spatial multi-omics and single-cell transcriptomics to identify senescence-associated programs in colon adenoma to cancer progression, finding GDF15 mediates senescence-stemness coupling and immune exclusion.

Dietary iron overload enhances susceptibility to Yersinia enterocolitica infection

This study shows that dietary iron overload increases susceptibility to Yersinia enterocolitica infection in mice, with iron chelation therapies being harmful during infection.

Label free multimodal optical imaging of metabolic heterogeneity and correlation in aging by integrating SRS, MPF, FLIM, and SHG

The paper introduces MANIFEST, a label-free imaging platform that integrates multiple optical modalities to analyze metabolic heterogeneity and spatial correlations in aging and disease models.

Concordia: Spatial Domain Detection via Augmented Graphs for Population-Level Spatial Proteomics

Concordia detects spatial domains in population-level spatial proteomics data using a GNN-based framework, revealing a cancer-associated fibroblast subset linked to clinical outcomes in lung cancer.

CausalGRN: deciphering causal gene regulatory networks from single-cell CRISPR screens

CausalGRN infers causal gene regulatory networks from single-cell CRISPR screens and predicts responses to unseen perturbations with improved accuracy.

A stem cell knockout village reveals lineage rewiring and a non-canonical islet cell fate in monogenic diabetes

This study uses a knockout village framework to analyze how mutations in diabetes genes alter pancreatic beta cell development, revealing non-canonical cell fate shifts and identifying ISL1 as a key regulator.

A 3D Image Segmentation Study of U-Net on CT Images of the Human Aorta with Morphologically Diverse Anatomy

This study compares 2D and 3D U-Net for segmenting human aorta from CT images, finding 3D U-Net performs better but has geometry reconstruction errors.