John Y.-J. Shyy

This study shows that obesity increases atherosclerosis through an inter-tissue miR-30e-SLC7A11 axis, where adipose-derived miR-30e-5p targets SLC7A11 in vascular endothelial cells, leading to metabolic and functional impairments.

The paper introduces MANIFEST, a label-free imaging platform that integrates multiple optical modalities to analyze metabolic heterogeneity and spatial correlations in aging and disease models.

This study identifies MRG15 as a mechanosensitive suppressor of atherosclerosis by showing its role in regulating endothelial inflammation and adhesion pathways under disturbed flow.

This study shows that ACE2 phosphorylation at Ser-680 modulates angiogenesis by affecting AP-1 activation in vascular endothelial cells.

This study identifies miR-148a-3p as a key mediator of CKD-induced hyperlipidemia and atherosclerosis by targeting SIK1/AMPK1 in the liver via exosomal transfer.

This study identifies Dab2 and FoxM1 as key regulators of endothelial dysfunction in diabetes, showing that restoring Dab2 improves angiogenesis and wound healing.

The paper identifies smooth muscle Cxcl12 activation as a contributor to vascular remodeling in flow-induced pulmonary hypertension using a new murine model.

This study shows that oxidative stress modifies miR-483 to 8OH-G miR-483, leading to endothelial dysfunction and increased atherosclerosis risk through altered targetomes.