Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury
Yaying Zhu, Chengxiang Deng, Bo Chen, Jia He, Yanan Liu, Shan Lei, Weiju Lu, Cheng Peng, Zhao Shan
The paper identifies a stress-response program in mid-zone hepatocytes during early acute liver injury that suppresses proliferation via the Atf4-Chop-Btg2 axis.
eLife · Oct 26, 2026Peer-reviewedPharmacology & Toxicology