CASP3-GSDME-mediated trophoblast pyroptosis contributes to systemic inflammation
Baoying Huang, Shilei Bi, Weinan Deng, Lili Du, Lijun Huang, Yifan Wang, Lizi Zhang, Zhoushan Feng, Tengfei Liu, Julia G. Kzhyshkowska, Zhaowei Tu, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang
The paper identifies CASP3-GSDME-mediated trophoblast pyroptosis as a driver of systemic inflammation in early-onset preeclampsia and shows Vitamin D suppresses this process.
bioRxiv · Aug 21, 2025 · PreprintCell Biology