Single-Molecule Methods to Investigate Mechanisms of Transcription by RNA Polymerase of Mycobacterium tuberculosis
Wenxia Lin, Omar Herrera-Asmat, Alex Tong, Tiantian Kong, Carlos Bustamante
Methods · Jun 29, 2026Peer-reviewedBiophysics
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Wenxia Lin, Omar Herrera-Asmat, Alex Tong, Tiantian Kong, Carlos Bustamante
Methods · Jun 29, 2026Peer-reviewedBiophysics
Omar Herrera-Asmat, Alex Tong, Wenxia Lin, Tiantian Kong, Juan R. Del Valle, Daniel G. Guerra, Yon W. Ebright, Richard H. Ebright, Carlos Bustamante
This study characterizes the effects of three small-molecule inhibitors on MtbRNAP transcription elongation using optical tweezers, revealing distinct inhibition mechanisms and synergistic effects.
eLife · Oct 3, 2025Peer-reviewedBiophysics