BiophysicseLifePeer-reviewed
Pleomorphic effects of three small-molecule inhibitors on transcription elongation by Mycobacterium tuberculosis RNA polymerase
Omar Herrera-Asmat, Alex Tong, Wenxia Lin…·Carlos Bustamante
This study characterizes the effects of three small-molecule inhibitors on MtbRNAP transcription elongation using optical tweezers, revealing distinct inhibition mechanisms and synergistic effects.