Spatial atlas highlights contribution of C. difficile in early-stage colorectal cancer
Nicholas O. Markham, Julia L. Drewes, Emily H. Green, William Ball, Hannah M. Lunnemann, Alan J. Simmons, Harsimran Kaur, Jessica Queen, Abby L. Geis, Maryam Pourmaleki, Bryan R. Helm, Erik P. Storrs, Marisol A Ramirez-Solano, Xiang Li, Zhicheng Ma, , Robert J. Coffey
The paper creates a spatial atlas of early-stage colorectal cancer tumors to identify bacterial niches and their impact on tumor transcriptomes, highlighting C. difficile's significant influence despite low abundance.
bioRxiv · Jun 20, 2026 · PreprintCancer Biology