Xiang Li

TET loss of function selects for aneuploidies that confer a proliferative advantage

This study shows that TET loss of function promotes aneuploidy, particularly chromosome 17 trisomy, which provides a proliferative advantage in iNKT cells and mESCs.

The RNA modification N6-methyladenosine restrains SIRPα to license myeloid efferocytosis in atherosclerosis

This study identifies the m6A-SIRP axis as a regulator of efferocytosis in atherosclerosis, showing myeloid m6A loss increases plaque instability.

Population genomics of the rice landrace Acuce reveals exceptional dynamics of immune receptors

The paper analyzes genomic diversity in the rice landrace Acuce to understand its resistance to pathogens and agricultural traits, finding high diversity and selection pressures in immunity genes.

Genome Sequencing of Rice Landraces from the Yuanyang Terraces Uncovers Ancient and Diverse Lineages of Indica Rice

This study analyzes genetic diversity in rice landraces from the Yuanyang Terraces, finding high genetic variation and differences in immune gene evolution between traditional and modern rice varieties.

Effect of dietary Chitosan supplementation on Intestinal Barrier Function and Growth Performance in weaned piglets challenged by Enterohemorrhagic haemolytic Escherichia coli

This study shows that dietary chitosan supplementation improves growth performance and intestinal barrier function in weaned pigs challenged by EHEC.

Spatial atlas highlights contribution of C. difficile in early-stage colorectal cancer

The paper creates a spatial atlas of early-stage colorectal cancer tumors to identify bacterial niches and their impact on tumor transcriptomes, highlighting C. difficile's significant influence despite low abundance.

Discovery of a Novel Coltivirus in a Newly Identified Bat Bug Species (Heteroptera: Cimicidae) in Cambodia

This study identifies a novel coltivirus in a new bat bug species from Cambodia, highlighting the role of bat ectoparasites as potential reservoirs of zoonotic viruses.

An LSEC-focused computational drug repurposing platform for liver fibrosis: Identification of vorinostat and other LSEC-protective candidates

This paper develops a computational platform to repurpose drugs for liver fibrosis by focusing on LSECs, identifying vorinostat and other candidates that protect LSECs.

An in situ generated CAR-M with IFNg and negative dominance Sirpa isoform augments hepatocellular carcinoma immunotherapy

This paper develops a novel CAR-M targeting GPC3 with IFN-gamma and SIRPECD to enhance anti-tumor activity in hepatocellular carcinoma.

Interactive Effects of Biological Maturation and Relative Age Effect on Talent Identification for U16 Elite Soccer Players

This study examines how biological maturation and relative age effect influence talent identification in U16 elite soccer players, finding significant impacts of maturation on physical and performance metrics but not on selection criteria.

Haemagglutinin 162-164 deletions enhance influenza B/Victoria virus fitness and virulence in vivo

This study shows that HA deletions and substitutions in influenza B/Victoria viruses enhance replication and virulence, contributing to their evolutionary success and vaccine challenges.

Developing High-Yield and Safe Therapeutic EVs by Ablating Tissue Factor-Mediated Toxicity

This paper develops a genetically engineered EV platform that increases yield and eliminates toxicity, enabling safe high-dose systemic delivery.

OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

This study shows that OGT inhibits TET activity, preventing DNA demethylation and transposable element expression in heterochromatin.

Screening for functional circular RNAs using the CRISPR-Cas13 system

This study uses CRISPR-Cas13 to functionally screen circRNAs, identifying roles in cell growth and development.

STRESS-INDUCED GENETIC CHANGE IN FLAX REVEALS GENOME VARIATION MECHANISM

This study identifies stress-induced genetic changes in flax that reveal a non-random mechanism of genome reorganization and variation.

The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem

The paper derives a fine mapping theorem showing how disease association statistics decay with declining linkage disequilibrium from a causal site, applicable across inheritance modes.

Spatial epidemiology of networked metapopulation: An overview

This paper reviews spatial metapopulation dynamics to model and evaluate disease intervention strategies for emerging infectious diseases.