NOTCH-driven oscillations control cell fate decisions during intestinal homeostasis
Sonja D. C. Weterings, Hiromune Eto, Jan-Daniël de Leede-Scheven, Amir Giladi, Jooske L. Monster, Mirjam E. Hoekstra, Wouter F. Beijk, Esther J. M. Liefting, Karen B. van den Anker, Jacco van Rheenen, Alexander van Oudenaarden, Katharina F. Sonnen
The paper shows that NOTCH-driven Hes1 oscillations with different periods control cell fate decisions in intestinal stem cells, influencing secretory and absorptive lineage commitment.
Science · Oct 15, 2026Peer-reviewedCell Biology