Jacco van Rheenen

The paper shows that NOTCH-driven Hes1 oscillations with different periods control cell fate decisions in intestinal stem cells, influencing secretory and absorptive lineage commitment.

This study uses expansion microscopy to analyze three-dimensional ultrastructure of intestinal tissues and organoids, revealing disease-specific phenotypes in a microvillus inclusion disease model.

This study shows cancer cells follow intrinsic self-organized programs that coordinate tumor cell state transitions during growth, revealing mechanical gradients and stereotyped patterns of heterogeneity and plasticity.

This study shows that mechanical signals from the Collagen I-rich matrix drive fate transitions in colorectal cancer cells, enabling metastasis despite lacking Lgr5 expression.

The paper identifies sequential transcriptomic states of tuft cells along the intestinal crypt-villus axis and shows cytokine-specific differentiation into distinct tuft cell phenotypes.

Polytope enables high-resolution spatial fate-mapping by generating unique color codes through epitope barcoding in vivo.

The paper shows that nucleocytoplasmic transport (NCT) in cell monolayers responds to mechanical forces but not cell density, contrasting with YAP's response to both mechanics and cell density.