Author

X. Charpentier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 11

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:bacteria (other)· 5 Research Focus:chromatin & epigenetic regulation· 5 Research Focus:gene regulatory network inference· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:whole-genome sequencing· 4 Approach:statistical model· 3

Frequent Co-Authors

M.-H. Laaberki· 6 shared A.-S. Godeux· 5 shared S. Venner· 3 shared A. Lupo· 2 shared E. Svedholm· 2 shared G. Carvalho· 2 shared I. Durieux· 2 shared L. Hardy· 2 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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6 shared papersMicrobiology

M.-H. Laaberki

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11 papers

Recent·Most cited

Interplay between the Xer recombination system and the dissemination of antibioresistance in Acinetobacter baumannii

C. Blanchais, C. Pages, M. Campos, K. Boubekeur, R. Contarin, M. Orlando, P. Siguier, M.-H. Laaberki, F. Cornet, X. Charpentier, P. ROUSSEAU

This study investigates how the Xer recombination system in Acinetobacter baumannii facilitates plasmid co-integration and gene exchange, contributing to the spread of antibiotic resistance.

bioRxiv · Apr 9, 2024 · PreprintMicrobiology

Two D-loop resolution systems enable natural genetic transformation in bacteria

L. Hardy, V. Morales, C. J. Rousseau, M. Berge, J. Plantade, F. Mazzamurro, T. N. Dalia, A. B. Dalia, E. P. C. Rocha, X. Charpentier, P. Polard

This study identifies two D-loop resolution systems in bacteria, YraN/ComM and CoiA/RadA, that work together to process the transformation D-loop during natural genetic transformation.

bioRxiv · Feb 6, 2024Microbiology

Manipulation of natural transformation by AbaR-type islands promotes fixation of antibiotic resistance in Acinetobacter baumannii populations

R. Tuffet, G. Carvalho, A.-S. Godeux, M.-H. Laaberki, S. Venner, X. Charpentier

This study shows AbaR-type islands persist in Acinetobacter baumannii by integrating into comM, reducing their removal while allowing continued genetic exchange.

bioRxiv · Oct 6, 2023 · PreprintMicrobiology

Interbacterial transfer of carbapenem resistance and large antibiotic resistance islands by natural transformation in pathogenic Acinetobacter

A.-S. Godeux, E. Svedholm, S. Barreto, A. Potron, S. Venner, X. Charpentier, M.-H. Laaberki

This study demonstrates that natural transformation facilitates interbacterial transfer of carbapenem resistance and large resistance islands in Acinetobacter species.

bioRxiv · Aug 5, 2021Microbiology

Deciphering Legionella effector delivery by Icm/Dot secretion system reveals a new role for c-diGMP signaling

J. Allombert, C. Jaboulay, C. Michard, C. Andrea, X. Charpentier, A. Vianney, P. Doublet

The paper investigates the dynamics of multi-effector secretion by the Legionella pneumophila Icm/Dot T4SS and identifies c-diGMP signaling as a regulator of effector translocation timing.

bioRxiv · Apr 22, 2021 · PreprintMicrobiology

Transposon-insertion sequencing in a clinical isolate of Legionella pneumophila identifies essential genes and determinants of natural transformation

L. Hardy, P.-A. Juan, B. Coupat-Goutaland, X. Charpentier

bioRxiv · Oct 1, 2020Microbiology

Scarless removal of large resistance island AbaR results in antibiotic susceptibility and increased natural transformability in Acinetobacter baumannii.

A.-S. Godeux, E. Svedholm, A. Lupo, M. Haenni, M.-H. Laaberki, X. Charpentier

This study removes AbaR islands from Acinetobacter baumannii strains, showing increased antibiotic susceptibility and natural transformability.

bioRxiv · Apr 29, 2020Microbiology

Diverse conjugative elements silence natural transformation in Legionella species

I. Durieux, C. Ginevra, L. Attaiech, K. Picq, P.-A. Juan, S. Jarraud, X. Charpentier

This study identifies a plasmid-encoded small RNA that silences natural transformation in Legionella species, explaining intraspecific variation in transformability.

bioRxiv · May 27, 2019Microbiology

Bacterial transformation buffers environmental fluctuations through the reversible integration of mobile genetic elements

G. Carvalho, D. Fouchet, G. Danesh, A.-S. Godeux, M.-H. Laaberki, D. Pontier, X. Charpentier, S. Venner

This study shows that bacterial transformation optimizes fitness in fluctuating environments by reversibly integrating beneficial mobile genetic elements.

bioRxiv · Feb 24, 2019Microbiology

Fluorescence-based detection of natural transformation in drug resistant Acinetobacter baumannii

A.-S. Godeux, A. Lupo, M. Haenni, S. Guette-Marquet, G. Wilharm, M.-H. Laaberki, X. Charpentier

This paper develops a flow cytometry-based method to detect natural transformation in multidrug-resistant Acinetobacter baumannii without antibiotic selection.

bioRxiv · Mar 2, 2018Microbiology

KKL-35 Exhibits Potent Antibiotic Activity Against Legionella Species Independently Of Trans-Translation Inhibition

R. Brunel, G. Descours, I. Durieux, P. Doublet, S. Jarraud, X. Charpentier

This study shows KKL-35, an oxadiazole compound, effectively inhibits Legionella species growth without relying on trans-translation inhibition.

bioRxiv · Nov 15, 2017Microbiology