Allosteric Modulation of MIF-2 Structure, Catalysis, and Biological Signaling via Cysteine Residues and a Small Molecule, Ebselen
Vinnie Widjaja, Sirena M. D’Orazio, Pragnya Das, Xander Takada, Divya Rajendran, Yuanjun Shi, Iz Varghese, Yannie Lam, Jimin Wang, Víctor S. Batista, Vineet Bhandari, George P. Lisi
This study investigates how Ebselen modulates MIF-2 structure, catalysis, and signaling through cysteine residues, revealing its impact on trimer stability and function.
bioRxiv · May 15, 2025 · PreprintBiophysics